What is Mesenchymal Stem Cell?
Mesenchymal Stem Cell (MSCs) are a kind of multipotent adult stem cells that are distributed in the capillaries of multiple tissues of the human body and have the ability to self-renew, multi-lineage differentiation and “Secrectome”. Many researchers consider the transplantation of MSCs to be the most effective tool for cell therapy.
What is Mesenchymal Stem Cell?



Identity MSCs

Minimal Criteria By ISCT

01
Plastic Adherent
Plastic Adherent
Be plastic-adherent when maintained in standard culture condition
02
Multi-lineage Differentiation
Multi-lineage Differentiation
Differentiate into Osteoblast, adipocytes, and chondroblasts in vitro.
03
CD Markers Expression
CD Markers Expression
Positive: CD73, CD90, CD105
Negative: CD11a, CD19, CD34, CD45, CD79a, HLA-Dr



Mechanisms

201
Genes
247
Proteins
30
Pathways
58
Processes


UC-MSC UC-MSC

Immune Privilege

The absence of major histocompatibility complex (MHC)/human leukocyte antigen(HLA) class II and associated costimulatory molecules and low levels of MHC/HLA class I.

Migration

Pathological tissue releases a variety of inflammatory factors, prompting MSCs to accumulate at sites through micro vessels, thereby releasing cytokines to repairing.

Proliferation Potential

Highly proliferative potential and telomerase activity. The proliferation rate is no significantly reduced and the karyotype is stable even for 30 passages

Paracrine

Secret a wide array of bioactive factors such as growth factors, cytokines, and chemokines to activate endogenous stem cells and regulate immune cells.

Exosomes

Extracellular vesicles that contain proteins, lipids and RNAs reduce the secretion of pro-inflammatory cytokines and increase the production of TGF-β.

Angiogenesis

Promote angiogenesis through paracrine angiogenic factors (VEGF, IL-6, etc.) and promote endothelial cell proliferation and migration.

Immunomodulatory

Through cell-to-cell contact and paracrine, MSCs modulate the proliferation, differentiation, and mechanisms of immune cells to regulate the immune system and suppress inflammation.

Mitochondrial Transfer

The capability of MSCs to transfer their own mitochondria into mtDNA depleted cells was shown with a high expression of RHOT1.

Multilineage Differentiation

MSCs showed high differentiation capacity, not only osteoblasts, adipocytes, chondrocytes, but also cardiomyocytes, smooth muscle cells, etc.



9 Features

What is Clinical Grade

  1. Tests per FDA Criteria
  2. Standard Stem Cell Bank
  3. Donor Screenings
  4. Fresh Cell Suspension
  5. Effective IND
  6. cGMP laboratory
  7. High Purity
  8. High Viability
  9. High Biological Potency
9 Features: What is Clinical Grade



10 Steps

FDA Compliant Procedures

10 Steps: FDA Compliant Procedures
  1. Screenings
  2. Isolation
  3. Culture
  4. Identification
  5. Banking
  6. Thawing
  7. Optimization
  8. Harvest
  9. Examination
  10. Filling

At Bright Cell Healthcare Institutes, we understand that the safety in the use of our products depends on their simplicity. Our focus is to develop accessible, safe, and user-friendly products.
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